The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

雅典娜2.0是一家亚历克萨奖的社会奖，这是最后两个Alexa奖奖挑战的决赛。雅典娜成功的一个原因是其新的对话管理战略，它允许它动态构建组件模块的对话和响应，导致每个互动的新型对话。在这里，我们在20/21竞争期间描述了Athena的Alexa奖的系统设计和性能。雅典娜的活跃演示以及视频录音将挑起对话AI的艺术状态的讨论。

开放式对话系统的一个挑战是需要对任何主题产生真实，高质量的响应。我们的目标是提高Athena的质量和覆盖，Alexa奖项对话系统。我们试验几次以初步的提示学习，将GPT-Neo与侏罗纪-1比较，用于电影，音乐，电视，运动和视频游戏域，包括不同的提示设定大小（2， 3,10），格式和意义表示由一组Wikidata Kg三元组或对话行为组成。我们的评估使用BLEurt和人类指标，并表明，随着10次提示，雅典娜 - 侏罗纪的表现对于连贯性和语义准确性明显更好。 2-Shot跨域提示的实验导致雅典娜-GPT-NEO的巨大性能下降，其语义精度下降至0.41，其不真实的幻率增加到12％。对对话行为进行视频游戏的实验表明，随着10次提示，两种模型都学会控制对话行为，但犹太犹太人的一致性较高，只有4％的幻觉。我们的结果表明，雅典娜 - 侏罗纪产生足够高的质量产出，可用于具有真实用户的现场系统。据我们所知，这些是第一个展示基于几枪语的语义及时的学习的第一次结果，可以创建对新域推广的NLG，并直接从意义表示产生高质量，语义控制的会话响应。

Remote sensing imagery provides comprehensive views of the Earth, where different sensors collect complementary data at different spatial scales. Large, pretrained models are commonly finetuned with imagery that is heavily augmented to mimic different conditions and scales, with the resulting models used for various tasks with imagery from a range of spatial scales. Such models overlook scale-specific information in the data. In this paper, we present Scale-MAE, a pretraining method that explicitly learns relationships between data at different, known scales throughout the pretraining process. Scale-MAE pretrains a network by masking an input image at a known input scale, where the area of the Earth covered by the image determines the scale of the ViT positional encoding, not the image resolution. Scale-MAE encodes the masked image with a standard ViT backbone, and then decodes the masked image through a bandpass filter to reconstruct low/high frequency images at lower/higher scales. We find that tasking the network with reconstructing both low/high frequency images leads to robust multiscale representations for remote sensing imagery. Scale-MAE achieves an average of a $5.0\%$ non-parametric kNN classification improvement across eight remote sensing datasets compared to current state-of-the-art and obtains a $0.9$ mIoU to $3.8$ mIoU improvement on the SpaceNet building segmentation transfer task for a range of evaluation scales.

Variance parameter estimation in linear mixed models is a challenge for many classical nonlinear optimization algorithms due to the positive-definiteness constraint of the random effects covariance matrix. We take a completely novel view on parameter estimation in linear mixed models by exploiting the intrinsic geometry of the parameter space. We formulate the problem of residual maximum likelihood estimation as an optimization problem on a Riemannian manifold. Based on the introduced formulation, we give geometric higher-order information on the problem via the Riemannian gradient and the Riemannian Hessian. Based on that, we test our approach with Riemannian optimization algorithms numerically. Our approach yields a higher quality of the variance parameter estimates compared to existing approaches.

Given ample experimental data from a system governed by differential equations, it is possible to use deep learning techniques to construct the underlying differential operators. In this work we perform symbolic discovery of differential operators in a situation where there is sparse experimental data. This small data regime in machine learning can be made tractable by providing our algorithms with prior information about the underlying dynamics. Physics Informed Neural Networks (PINNs) have been very successful in this regime (reconstructing entire ODE solutions using only a single point or entire PDE solutions with very few measurements of the initial condition). We modify the PINN approach by adding a neural network that learns a representation of unknown hidden terms in the differential equation. The algorithm yields both a surrogate solution to the differential equation and a black-box representation of the hidden terms. These hidden term neural networks can then be converted into symbolic equations using symbolic regression techniques like AI Feynman. In order to achieve convergence of these neural networks, we provide our algorithms with (noisy) measurements of both the initial condition as well as (synthetic) experimental data obtained at later times. We demonstrate strong performance of this approach even when provided with very few measurements of noisy data in both the ODE and PDE regime.

Timely and effective feedback within surgical training plays a critical role in developing the skills required to perform safe and efficient surgery. Feedback from expert surgeons, while especially valuable in this regard, is challenging to acquire due to their typically busy schedules, and may be subject to biases. Formal assessment procedures like OSATS and GEARS attempt to provide objective measures of skill, but remain time-consuming. With advances in machine learning there is an opportunity for fast and objective automated feedback on technical skills. The SimSurgSkill 2021 challenge (hosted as a sub-challenge of EndoVis at MICCAI 2021) aimed to promote and foster work in this endeavor. Using virtual reality (VR) surgical tasks, competitors were tasked with localizing instruments and predicting surgical skill. Here we summarize the winning approaches and how they performed. Using this publicly available dataset and results as a springboard, future work may enable more efficient training of surgeons with advances in surgical data science. The dataset can be accessed from https://console.cloud.google.com/storage/browser/isi-simsurgskill-2021.

Class-Incremental Learning is a challenging problem in machine learning that aims to extend previously trained neural networks with new classes. This is especially useful if the system is able to classify new objects despite the original training data being unavailable. While the semantic segmentation problem has received less attention than classification, it poses distinct problems and challenges since previous and future target classes can be unlabeled in the images of a single increment. In this case, the background, past and future classes are correlated and there exist a background-shift. In this paper, we address the problem of how to model unlabeled classes while avoiding spurious feature clustering of future uncorrelated classes. We propose to use Evidential Deep Learning to model the evidence of the classes as a Dirichlet distribution. Our method factorizes the problem into a separate foreground class probability, calculated by the expected value of the Dirichlet distribution, and an unknown class (background) probability corresponding to the uncertainty of the estimate. In our novel formulation, the background probability is implicitly modeled, avoiding the feature space clustering that comes from forcing the model to output a high background score for pixels that are not labeled as objects. Experiments on the incremental Pascal VOC, and ADE20k benchmarks show that our method is superior to state-of-the-art, especially when repeatedly learning new classes with increasing number of increments.

Intensive Care Units usually carry patients with a serious risk of mortality. Recent research has shown the ability of Machine Learning to indicate the patients' mortality risk and point physicians toward individuals with a heightened need for care. Nevertheless, healthcare data is often subject to privacy regulations and can therefore not be easily shared in order to build Centralized Machine Learning models that use the combined data of multiple hospitals. Federated Learning is a Machine Learning framework designed for data privacy that can be used to circumvent this problem. In this study, we evaluate the ability of deep Federated Learning to predict the risk of Intensive Care Unit mortality at an early stage. We compare the predictive performance of Federated, Centralized, and Local Machine Learning in terms of AUPRC, F1-score, and AUROC. Our results show that Federated Learning performs equally well as the centralized approach and is substantially better than the local approach, thus providing a viable solution for early Intensive Care Unit mortality prediction. In addition, we show that the prediction performance is higher when the patient history window is closer to discharge or death. Finally, we show that using the F1-score as an early stopping metric can stabilize and increase the performance of our approach for the task at hand.

Deep learning-based pose estimation algorithms can successfully estimate the pose of objects in an image, especially in the field of color images. 6D Object pose estimation based on deep learning models for X-ray images often use custom architectures that employ extensive CAD models and simulated data for training purposes. Recent RGB-based methods opt to solve pose estimation problems using small datasets, making them more attractive for the X-ray domain where medical data is scarcely available. We refine an existing RGB-based model (SingleShotPose) to estimate the 6D pose of a marked cube from grayscale X-ray images by creating a generic solution trained on only real X-ray data and adjusted for X-ray acquisition geometry. The model regresses 2D control points and calculates the pose through 2D/3D correspondences using Perspective-n-Point(PnP), allowing a single trained model to be used across all supporting cone-beam-based X-ray geometries. Since modern X-ray systems continuously adjust acquisition parameters during a procedure, it is essential for such a pose estimation network to consider these parameters in order to be deployed successfully and find a real use case. With a 5-cm/5-degree accuracy of 93% and an average 3D rotation error of 2.2 degrees, the results of the proposed approach are comparable with state-of-the-art alternatives, while requiring significantly less real training examples and being applicable in real-time applications.